CD34 Rabbit Polyclonal Antibody（0108-2）

如有找不到的抗体产品，欢迎直接联系客服咨询！

概述	Overview	概述
产品名称	CD34 Rabbit Polyclonal Antibody	CD34 兔多克隆抗体
抗体类型	Rabbit Polyclonal Antibody	兔多克隆抗体
免疫原	Synthetic peptide within human CD34 aa 336-385.	人源 CD34 氨基酸 336-385 的合成肽
种属反应性	Human, Mouse, Zebrafish	人、小鼠、斑马鱼
验证应用	WB, IF-Cell, IHC-P	蛋白质印迹（WB），细胞免疫荧光（IF-Cell），免疫组化（IHC-P）
分子量	Predicted band size: 41 kDa	预测条带大小：41 kDa
阳性对照	Human brain, mouse brain, mouse testis, Mouse thymus, mouse spleen, Jurkat, TF-1, F9, human embryonic stem cell, human tonsil tissue	人脑、小鼠脑、小鼠睾丸、小鼠胸腺、小鼠脾脏、Jurkat 细胞、TF-1 细胞、F9 细胞、人胚胎干细胞、人扁桃体组织
偶联	Unconjugated	非偶联
RRID	AB_3096758	AB_3096758
产品特性	Product Characteristics	产品特性
形态	Liquid	液体
浓度	1ug/ul	1微克/微升
存放说明	Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.	解冻后存放于 +4℃。分装后存放于 -20℃ 或 -80℃。避免反复冻融。
存储缓冲液	1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.	1*PBS (pH7.4), 0.2% BSA, 40% 甘油。防腐剂：0.05% 叠氮化钠。
亚型	IgG	IgG
纯化方式	Immunogen affinity purified.	免疫原亲和纯化
应用稀释度	Application Dilution	应用稀释度
WB	1:500-1:1,000	1:500-1:1,000
IF-Cell	1:100	1:100
IHC-P	1:3,000	1:3,000
靶点	Target	靶点
功能	CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species. The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early haematopoietic and vascular-associated progenitor cells. However, little is known about its exact function. CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node endothelia, whereas the L-selectin to which it binds is on the T cell. Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumina. Finally, recent data suggest CD34 may also play a more selective role in chemokine-dependent migration of eosinophils and dendritic cell precursors. Regardless of its mode of action, under all circumstances CD34, and its relatives podocalyxin and endoglycan, facilitates cell migration.	CD34 是一种跨膜磷糖蛋白，由人类、小鼠、大鼠等物种的 CD34 基因编码。CD34 蛋白是单次跨膜唾液黏蛋白家族的一员，在早期造血和血管相关祖细胞上表达。然而，其确切功能尚不清楚。CD34 也是一种重要的黏附分子，是 T 细胞进入淋巴结所必需的。它在淋巴结内皮上表达，而与其结合的 L-选择素则在 T 细胞上。相反，在其他情况下，CD34 被证明可以充当分子“特氟龙”，阻止肥大细胞、嗜酸性粒细胞和树突状细胞前体的黏附，并促进血管腔的开放。最后，最近的数据表明，CD34 可能在嗜酸性粒细胞和树突状细胞前体的趋化因子依赖性迁移中发挥更选择性的作用。无论其作用模式如何，在所有情况下，CD34 及其相关蛋白 podocalyxin 和 endoglycan 都促进细胞迁移。
背景文献	Background Literature	背景文献
1	Freund D., Wiebe G.J., Ehninger G., Corbeil D.; "Sequence analysis of the human CD34 antigen."; Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.	Freund D., Wiebe G.J., Ehninger G., Corbeil D.; "人 CD34 抗原的序列分析。"; 提交于 2002 年 6 月到 EMBL/GenBank/DDBJ 数据库。
2	The MGC Project Team;"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).	MGC 项目团队；"NIH 全长 cDNA 项目的状态、质量和扩展：哺乳动物基因集合 (MGC)。"; 基因组研究 14:2121-2127(2004)。
3	Sutherland D.R., Watt S.M., Dowden G., Karhi K., Baker M.A., Greaves M.F., Smart J.E.;"Structural and partial amino acid sequence analysis of the human hemopoietic progenitor cell antigen CD34.";Leukemia 2:793-803(1988).	Sutherland D.R., Watt S.M., Dowden G., Karhi K., Baker M.A., Greaves M.F., Smart J.E.;"人造血祖细胞抗原 CD34 的结构和部分氨基酸序列分析。"; 白血病 2:793-803(1988)。
序列相似性	Sequence Similarity	序列相似性
	Belongs to the CD34 family.	属于 CD34 家族。
组织特异性	Tissue Specificity	组织特异性
	Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.	选择性表达于造血祖细胞和各种组织的小血管内皮。
翻译后修饰	Post-translational Modifications	翻译后修饰
	Highly glycosylated.; Phosphorylated on serine residues by PKC.	高度糖基化；通过 PKC 在丝氨酸残基上磷酸化。
亚细胞定位	Subcellular Location	亚细胞定位
	Cell membrane	细胞膜
UNIPROT #	SwissProt: P28906 Human, SwissProt: Q64314 Mouse	SwissProt: P28906 人, SwissProt: Q64314 小鼠
别名	CD34 antibody, CD34 antigen antibody, CD34 molecule antibody, CD34_HUMAN antibody, Cluster designation 34 antibody, Hematopoietic progenitor cell antigen CD34 antibody, HPCA1 antibody, Mucosialin antibody, OTTHUMP00000034733 antibody, OTTHUMP00000034734 antibody	CD34 抗体, CD34 抗原抗体, CD34 分子抗体, CD34_HUMAN 抗体, 簇分化抗原 34 抗体, 造血祖细胞抗原 CD34 抗体, HPCA1 抗体, 黏蛋白抗体, OTTHUMP00000034733 抗体, OTTHUMP00000034734 抗体